From Vitasearch: 
| Summary# | 46435 | | Topic: | Low Selenium Status in Patients with PKU Linked to Reduced Cognitive Function | | Keywords: | PKU, PHENYLKETONURIA, COGNITIVE FUNCTION - Selenium, Antioxidant, Retinol, Tocopherol, Vitamin E, Coenzyme Q10, Malondialdehyde, Catalase | | Reference: | “Cognitive functions and the antioxidant system in phenylketonuric patients,” Gassio R, Artuch R, et al, Neuropsychology, 2008; 22(4): 426-31. (Address: PKU Follow-up Unit, Neuropediatrics Department, Hospital Sant Joan de Deu, Universitat de Barcelona, Spain). | | Summary: | In a study involving 36 early and continuously treated patients with phenylketonuria (PKU) and 29 controls, patients with PKU had significantly lower levels of selenium, coenzyme Q10, and catalase, and significantly higher levels of malondialdehyde, as compared with controls. Cognitive function was assessed as well. Low levels of selenium were associated with lower performance on tests of cognitive function (more omission errors, fluctuating attention, inconsistency of response times, and progressively slower reaction time) among PKU patients. The results of this study suggest that, “it is important not only to control blood Phe levels in PKU but also other nutritional components such as selenium.” |
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Filed under Nutrition, Research
Tags: Cognitive Function and Selenium, Low Selenium and Cognitive Impairment, Memory