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... s condition; abnormal loops in capillaries may also be involved. Altered levels of endothelial-derived factors occur, and endothelial damage may be related to the presence of autoantibodies (antibodies inappropriately made against the body's own molecules.) Research suggests that failure of endothelial regulation may contribute to abnormal vascular ...
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By Shihoko Okazaki and Colleague The objective of the study was to determine the presence or levels of antibodies (Abs) against caspase-3 and their clinical relevance in systemic sclerosis (SSc). Anti-caspase-3 Ab was examined by enzyme-linked immunosorbent assay and immunoblotting. IgG anti-caspase-3 Ab levels in SSc patients were higher than in ...
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By Jones, M. and Colleague Autoimmunity occurs when antibodies, known as autoantibodies, are made against bodily tissues that should not be recognized as foreign. Autoantibodies that are specific to certain types of cells have been found to be asso ...
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By Walker, Jennifer G; Fritzler, Marvin J Purpose of review: This is a review of autoantibodies described in systemic sclerosis with an emphasis on recently published studies. In the past, most, if not all of the discussion on this topic focused on antinuc ...
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By Jones, M. and Colleague Autoimmunity occurs when antibodies, known as autoantibodies, are made against bodily tissues that should not be recognized as foreign. Autoantibodies that are specific to certain types of cells have been found to be asso ...
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Latest research about antioxidant & sclerodermaBy Fumihide Ogawa and ColleagueAbstractSystemic sclerosis (SSc) is a connective tissue disease characterized by fibrosis and vascular changes in the skin and internal organs with autoimmune background. It has been suggested that oxidative stress plays an important role in the development of SSc. To ...
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Latest research about antioxidant & sclerodermaBy Fumihide Ogawa and ColleagueAbstractSystemic sclerosis (SSc) is a connective tissue disease characterized by fibrosis and vascular changes in the skin and internal organs with autoimmune background. It has been suggested that oxidative stress plays an important role in the development of SSc. To ...
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By F. Ogawa and ColleagueObjective. To determine serum levels and clinical correlation of 8-isoprostane, which is produced in vivo through free radical-catalysed peroxidation of arachidonic acid and reflects oxidative stress, in patients with systemic sclerosis (SSc). Methods. Serum 8-isoprostane levels from 32 patients with diffuse cutaneous SSc ( ...
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By Lewis J. Rubin and Colleague In April 2006, 30 international experts gathered in Athens, Greece, to discuss systemic sclerosis (SSc) and related connective tissue diseases (CTDs). SSc is a clinically heterogeneous and complex disease that is characterized by vascular dysfunction, vascular and extravascular fibrosis, and characteristic immune der ...
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... ls, hypochlorous acid, peroxynitrites, superoxide anions), bleomycin, or PBS everyday for 6 wk. Skin and lung fibrosis were assessed by histological and biochemical methods. Autoantibodies were detected by ELISA. The effects of mouse sera on H(2)O(2) production by endothelial cells and on fibroblast proliferation, and serum concentrations in advan ...
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