Fibroblast

The Best Buy of the Holiday Season: Kinerase Winter Skin Brightening Collection by Nicki Z. Patient Expert

... retinoin ( Retin-A ).An effective antioxidant Kinetin was been found in a 2000 study to be a strong inhibitor of oxidative and glycoxidative protein damage in cultured human fibroblasts (skin cells). In the study, kinetin proves to be a potent antioxidant by mimicking superoxide dismutase activity, activating superoxide dismutase and catalase, an ... Read on »

Product Review: Kate Somerville Deep Tissue Repair with Peptide K8 by Nicki Z. Patient Expert

... contains palmitoyl oligopeptide. What is great about palmitoyl oligopeptide is that it, like other prominent peptides, significantly stimulates collagen production in human fibroblasts, as shown in a 2007 study inDermatologic Therapy. On the other hand, palmitoyl oligopeptide has been found to down-regulate elastin expression. From one point of v ... Read on »

Increased Serum Pentraxin 3 in Patients with Systemic Sclerosis by Jan

... aneous SSc (lSSc), and 20 healthy controls were examined by ELISA. PTX3 expression in the sclerotic skin from SSc patients was evaluated immunohistochemically. Normal and SSc fibroblasts were cultured and PTX3 levels in the culture medium were also examined by ELISA. Results. Serum PTX3 levels were elevated in patients with SSc relative to control ... Read on »

Cinnamon and Hoelen Formula Inhibits Scleroderma Progression by Jan

... derma Progression Cinnamon and Hoelen significantly and selectively inhibits collagen synthesis in a dose dependent manner with a tendency of a stronger effect on scleroderma fibroblasts than control cells. These results may explain the clinical usefulness of this medicine in the treatment of scleroderma. Because of this inhibition of collagen synt ... Read on »

Systemic sclerosis and related connective tissue diseases: present and future by Jan

... ic of the pathophysiology of SSc and other CTDs. The authors present the available evidence suggesting that ET-1 may play a key role at the early stages of CTDs by activating fibroblasts and pericytes. As yet, the event triggering endothelial cell injury is unknown. Having established that there is a need to improve our understanding of the factor ... Read on »

Desmoplastic melanoma, a common missed diagnosis. by Dr.Prashant Jani Patient Expert

... scar . The epidermis is often atrophic and may or may not have a precursor (in situ) lesion. Characteristically, the tumor is in the dermis as spindled melanocytes resembling fibroblasts.Often, there is an edematous or desmoplastic stroma with scattered lymphoid aggregates. Perineural invasion is common.In about one third of the lesions, there are ... Read on »

Selective oxidation of DNA topoisomerase 1 induces systemic sclerosis in the mouse. by Jan

... sis were assessed by histological and biochemical methods. Autoantibodies were detected by ELISA. The effects of mouse sera on H(2)O(2) production by endothelial cells and on fibroblast proliferation, and serum concentrations in advanced oxidation protein products (AOPP) were compared with sera from patients with limited or diffuse SSc. We observed ... Read on »

Neutrophil respiratory burst is decreased in scleroderma and normalized by near-infrared mediated... by Jan

By Foerster J. and ColleagueBACKGROUND: The production of reactive oxygen species (ROS) by fibroblasts has been suggested to contribute to scleroderma pathogenesis. Infrared-mediated hyperthermia has recently been shown to be of benefit in scleroderma. AIM: As the c ... Read on »

Why Do I Have Morning Heel Pain? by NorthcoastFootcare ... nnective tissue structure in the bottom of the foot. The plantar fascia is similar in structure to a ligament and is composed of collagen, elastin, glycosaminoglycans (GAGs), fibroblasts and water. Type I collagen adds to the fascia’s considerable strength and the elastin increases elasticity, as the name implies. Glycosaminoglycans are long ... Read on »

Breakdown of the Plantar Fascia by NorthcoastFootcare ... nd which extends along the bottom of the foot. The structural make up of the plantar fascia consists of collagen, elastin, glycosaminoglycans and water. The primary cells are fibroblasts, which synthesize collagen. The primary component of the fascia is type I collagen which adds to the strength of the structure. Elastin is a protein which gives th ... Read on »

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