Mrna

What is Wrong with this Picture? by Thomas Tan Patient Expert

... arl Izumi should just focus on making good running shoes and worry less about the inevitability of human evolution. References:Norman et al. Strength, power, fiber types, and mRNA expression in trained men and women with different ACTN3 R577X genotypes. J. Appl. Physiol. 106: 959-965, 2009.Saunders et al. No association of the ACTN3 gene R577X poly ... Read on »

What is Wrong with this Picture? by Thomas Tan Patient Expert

... , read this insightful and balanced article " Is Running Barefoot Better for You?" in the New York Times. References:Norman et al. Strength, power, fiber types, and mRNA expression in trained men and women with different ACTN3 R577X genotypes. J. Appl. Physiol. 106: 959-965, 2009.Saunders et al. No association of the ACTN3 gene R577X poly ... Read on »

Too many SOX can be a bad thing by Mark Pool, MD ... ophageal SqCC. In lung SqCC, the peak in this segment contained four genes, including SOX2; in esophageal SqCC, the peak only included SOX2. Next, the authors measured SOX2 mRNA levels by RT-PCR in 27 lung SqCC with matched SNP data cases. Cases with SOX2 amplification were found to have higher mRNA expression but they also found several cases w ... Read on »

RNA interference - Part 1: an ancient antiviral by Jeremy As every textbook attests, three types of RNA have long been identified: messenger RNA (mRNA), transfer RNA (tRNA) and ribosomal RNA (rRNA). However, the past decade and a half hasn't been kind to this convenient list. Several other kinds of RNA have now demand ... Read on »

Capillary Regeneration in Scleroderma: Stem Cell Therapy Reverses Phenotype? by Jan

... thy associated with scleroderma is one of the major contributors to the clinical manifestations of the disease. Methodology/Principal Findings We used immunohistochemical and mRNA in situ hybridization techniques to characterize this vasculopathy and showed with morphometry that scleroderma has true capillary rarefaction. We compared skin biopsies ... Read on »

Serum nitric oxide (NO) levels in systemic sclerosis patients: correlation between NO levels and... by Jan

... by skin fibroblasts, skin fibroblast cultures were established from SSc patients and healthy volunteers. Reverse transcription-polymerase chain reaction indicated that NOS-2 mRNA was spontaneously expressed in cultured fibroblasts derived from SSc patients, but not in those derived from healthy normal controls. Immunohistochemical staining also sh ... Read on »

Variations of neuronal nitric oxide synthase in systemic sclerosis skin by Jan

... polymerase chain reaction and Western blotting. Results Immunohistochemical and biochemical data showed a decrease in PGP 9.5 and nNOS innervation and in their messenger RNA (mRNA) levels in lcSSc and dcSSc skin. In the edematous phase of SSc, a light alteration in cutaneous innervation was initiated and slowly progressed into the sclerotic phase, ... Read on »

Systemic sclerosis: vascular, pulmonary and immunological aspects by Jan

... (h) lymphocytes. We found a mixed Th1/Th2 reaction in SSc alveolar T cells expressing messenger for interferon gamma (Th1), IL-6 and IL-10 (both Th2). No particular cytokine mRNA profile distinguished alveolar T cells in ILD. Neutrophils invaded the bronchial epithelium, which seemed otherwise inert as levels of inflammatory cytokine sensitive tr ... Read on »

Oxidative stress regulates collagen synthesis and matrix metalloproteinase activity in cardiac... by Jan

... without affecting total protein synthesis ([(3)H]leucine incorporation). H(2)O(2) and XXO decreased the expression of procollagen alpha(1)(I), alpha(2)(I), and alpha(1)(III) mRNA but increased the expression of fibronectin mRNA, suggesting a selective transcriptional effect on collagen synthesis. H(2)O(2), but not XXO, also decreased the expressio ... Read on »

Chemokine expression by systemic sclerosis fibroblasts: Abnormal regulation of monocyte... by Jan

... contribution of systemic sclerosis (SSc) fibroblasts to chemokine production and its potential relevance to the pathogenesis of SSc. Methods The expression of messenger RNA (mRNA) for different C-C and C-X-C chemokines by SSc and normal fibroblasts was studied by RNase protection assay. Monocyte chemoattractant protein 1 (MCP-1) protein production ... Read on »

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