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M-spikes

Posted Jan 14 2009 8:35pm
Beth, from Beth's Blog, (see link) posted today on the MMA list asking for a scan of a protein electrophoresis with an M- Spike. Since the list won't take attachments, I'll post some of Richard's here.

Serum electropheresis separates the blood proteins into immunoglobulins and albumin. MM patients secrete an abnormal immunoglobulin called an M-protein, m for monoclonal. The amount of M-protein is a measure of disease activity.

Not all myeloma patients have abnormal M protein. Some pateints only secrete abnormal protein into the urine. This is known as Bence-Jones protein and is quantified with a urine electrophoresis.

Above is Richard's electrophoresis when he was on thalidomide and had no detectable M-spike.



Next is a M-spike of 1.9


Last one is 2.9.
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