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This new study in the New England Journal of Medicine 12/10/08 issue concludes:
A genetic susceptibility to both type 1 diabetes and celiac disease shares common alleles. These data suggest that common biologic mechanisms, such as autoimmunity-related tissue damage and intolerance to dietary antigens, may be etiologic features of both diseases.
Our results support further evaluation of the hypothesis that cereal and gluten consumption might be an environmental factor in type 1 diabetes, leading to the alteration of the function of the gut immune system and its relationship with the pancreatic immune system.
Furthermore, insulin and its precursors are major targets of the T and B lymphocyte autoreactive response in type 1 diabetes. Thus, one might speculate that bovine insulin in infant foods could enhance anti-insulin responses,3 particularly if there are genetically determined defects in oral tolerance predisposing to type 1 diabetes. Conversely, genes that are classified as autoimmunity genes, because they are associated with type 1 diabetes, contribute to celiac disease.
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This new study in the New England Journal of Medicine 12/10/08 issue concludes:
A genetic susceptibility to both type 1 diabetes and celiac disease shares common alleles. These data suggest that common biologic mechanisms, such as autoimmunity-related tissue damage and intolerance to dietary antigens, may be etiologic features of both diseases.
Our results support further evaluation of the hypothesis that cereal and gluten consumption might be an environmental factor in type 1 diabetes, leading to the alteration of the function of the gut immune system and its relationship with the pancreatic immune system.
Furthermore, insulin and its precursors are major targets of the T and B lymphocyte autoreactive response in type 1 diabetes. Thus, one might speculate that bovine insulin in infant foods could enhance anti-insulin responses,3 particularly if there are genetically determined defects in oral tolerance predisposing to type 1 diabetes. Conversely, genes that are classified as autoimmunity genes, because they are associated with type 1 diabetes, contribute to celiac disease.