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NSAID

Posted Nov 04 2009 10:04pm

NSAID are non steroidal anti inflamatory drugs.

Typical Brands (generic)

Aleve ®, Naprosyn ®, Anaprox ® (naproxen)

Advil ®, Motrin ®, (ibuprofen)

Mobic ® (meloxicam)

Aspirin

Celebrex® (celecoxib) : a newer NSAID with a decreased risk of GI irritation.  A good option for those over 65 years old who are taking baby aspirin (does not decrease anti-platelet effect of aspirin).

Mechanism of action:

They decrease inflammation by stopping enzymes that help produce prostaglandins – pro inflammatory agents.

Warnings:

Regular use of NSAIDs (other than aspirin) may decrease the anti platelet and cardio-protective effect of low dose aspirin. Therefore if you take a baby aspirin, wait two hours before taking other NSAIDs.

NSAIDs are associated with an increased risk of heart attack, stroke and worsening of hypertension. Check with your physician first if you have a history of heart problems or high risk of stroke or heart attack.

NSAIDs can compromise renal function. Caution must be used when taking NSAIDs with other medication that affect the kidney (e.g. diuretics and ACE inhibitors) and in patients with kidney disease.

NSAIDs may worsen liver disease.

NSAIDs may increase the chance of bleeding ulcers in the stomach or duodenum.

Formulations:

liquid, injection, oral tablets or capsules, chew tabs, suppositories

Uses:

  • inflamed joints, muscles or tendons (e.g. acute back pain, knee pain, tennis elbow)

  • headache

  • fever

Dosage:

See directions on over the counter bottles or discuss with your family physician as dosage depends on the particular NSAID and the age and weight of the individual.

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